منابع مشابه
Granulopoiesis in neutropenic disorders.
Evaluation of proliferative activity of granulocytic progenitor cells from marrows of neutropenic patients was performed by utilizing in vitro culture methods measuring granulocytic colony-forming capacity (CFC) and the proportion of granulocytic progenitor cells in the DNA synthetic (S) phase of the cell cycle. Except for low CFC values found in five patients with myeloid hypoplasia, the remai...
متن کاملGranulocyte-associated IgG in neutropenic disorders.
We applied a radiolabeled antiglobulin test to a study of patients with a variety of neutropenic disorders. After defining the nature of the interaction of radiolabeled anti-IgG with the neutrophil, we studied 16 patients with neutropenia of uncertain etiology and adequate bone marrow granulocyte precursors. Twelve of these 16 patients had increased neutrophil-associated IgG (PMN-IgG). Patients...
متن کاملDisorders of Erythropoiesis, Granulopoiesis and Thrombopoiesis
Bone marrow cellularity is mildly increased as a result of a moderate degree of erythroid hyperplasia. Erythropoiesis is micronormoblastic with erythroblasts being smaller than normal with scanty or ragged cytoplasm or with cytoplasmic vacuolation (Fig. 8.1). There is a minor degree of dyserythropoiesis. An iron stain shows siderotic granules to be severely reduced or absent and there is a comp...
متن کاملT lymphocytes involved in inhibition of granulopoiesis in two neutropenic patients are of the cytotoxic/suppressor (T3+T8+) subset.
T lymphocyte-mediated bone marrow failure is a recently recognized clinical disorder, but the T lymphocyte subsets responsible for mediating the inhibitory effect have not been identified. We obtained T lymphocytes from the bone marrow of two patients with T lymphocyte-mediated granulopoietic failure, exposed them to monoclonal antibodies (OKT3, OKT4, and OKT8) in cytotoxicity assays, then reco...
متن کاملRetinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model.
Despite advances in the therapeutic use of recombinant granulocyte colony-stimulating factor (G-CSF) to promote granulopoiesis of human hematopoietic stem cells (HSCs), neutropenia remains one of the most serious complications of cancer chemotherapy. We discovered that retinoid agonist Am80 (tamibarotene) is more potent than G-CSF in coordinating neutrophil differentiation and immunity developm...
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ژورنال
عنوان ژورنال: Blood
سال: 1973
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v41.6.753.753